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eHealthTutorial — Research Peptide Reviews
Investigational • Not FDA-approved

Experimental growth-hormone fragment

AOD-9604

AOD-9604 is a modified peptide fragment derived from the C-terminal region of human growth hormone. Its research record includes laboratory and mouse metabolic studies plus a published analysis of human trial safety data.

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Generic laboratory vial labeled AOD-9604, research use only
Generic research visual — not a commercial product
Compound typeModified growth-hormone peptide fragment
Evidence basePreclinical work and human safety analysis
Regulatory contextInvestigational / Not FDA-approved
Page purposeResearch and calculation

Compound calculator

AOD-9604 reconstitution calculator

Enter the values printed on your vial and the liquid volume you added to calculate concentration, liquid volume, and the corresponding mark on a U-100 syringe scale.

Selected peptide or compoundAOD-9604
Enter the total amount printed on the vial.
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Enter the liquid volume added in milliliters.
You provide this amount; the calculator does not select or recommend it.
Scale reference only; confirm the markings on the physical syringe.

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Enter the three required values to see the mathematical result.

This calculator performs arithmetic using values you enter. It does not select or recommend an amount, schedule, treatment, preparation method, or method of administration.

Research overview

What is AOD-9604?

AOD-9604 is a synthetic modified fragment of human growth hormone, not the intact hormone. An analytical study identifies it as the 177–191 C-terminal fragment with an additional tyrosine at the N-terminus: a 16-residue peptide. It should not be conflated with an unmodified growth-hormone fragment, and results for the full hormone should not automatically be attributed to it.

What has research examined?

In one published mouse experiment, researchers compared AOD-9604 with intact human growth hormone and saline in obese and lean mice. AOD-9604 was associated with reduced weight gain in obese mice and increased fat-oxidation measures; cell assays did not show the same growth-hormone-receptor binding or proliferation as intact hormone. A separate mouse study examined lipid-metabolism measures and beta-adrenergic pathways. These animal findings do not establish a human weight-loss benefit. A sponsor-associated publication also summarized safety observations from six randomized, placebo-controlled human development trials; that analysis addresses studied formulations and conditions, not the identity, sterility, efficacy, or safety of a research product sold today.

Important limitation

Mouse metabolic effects do not establish human effectiveness. A pooled analysis of human trial safety data is not proof that a supplier’s research vial is safe or suitable for any use. FDA has noted limited safety-related information and potential immunogenicity and impurity-characterization concerns for compounded AOD-9604; reported serious adverse events have uncertain causality. This page does not establish product identity, preparation, dose, or appropriate use in people or animals.

Research references

Calculation boundary

The calculator performs concentration arithmetic only when a user enters a mass and liquid volume. It does not verify identity, formulation, purity, sterility, stability, compatibility, biological-unit equivalence, or whether reconstitution applies to a particular product. Do not convert IU or other biological units to mg without an authoritative, exact-product relationship.

For research purposes only. This page is educational and is not medical or veterinary advice or a recommendation to purchase, prepare, administer, or use any product.