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eHealthTutorial — Research Peptide Reviews
Investigational • Not FDA-approved

Albumin-binding GHRH analogue research

CJC-1295 with DAC

The albumin-binding CJC-1295 analogue has been studied in small controlled trials measuring growth-hormone and IGF-I biomarkers in healthy adults. Biomarker responses do not establish clinical benefit or supplier-vial safety.

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Generic research visual — not a commercial product
Compound typeLong-acting GHRH analogue with affinity complex
Evidence baseSmall controlled human biomarker studies
Regulatory contextInvestigational / Not FDA-approved
Page purposeResearch and calculation

Compound calculator

CJC-1295 with DAC reconstitution calculator

Enter the values printed on your vial and the liquid volume you added to calculate concentration, liquid volume, and the corresponding mark on a U-100 syringe scale.

Selected peptide or compoundCJC-1295 with DAC
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This calculator performs arithmetic using values you enter. It does not select or recommend an amount, schedule, treatment, preparation method, or method of administration.

Research overview

What is CJC-1295 with DAC?

CJC-1295 with DAC is a modified growth-hormone-releasing-hormone analogue incorporating an albumin-binding drug-affinity complex. Its covalent association with endogenous albumin was investigated to extend exposure. The presence of DAC distinguishes it from the “no DAC” supplier term; studies of one form cannot be assigned to the other.

What has research examined?

Two randomized, placebo-controlled ascending-dose studies measured hormone and pharmacokinetic endpoints in healthy adults. The reported mean GH and IGF-I biomarkers rose after studied CJC-1295 exposure, and the reported estimated half-life was several days. A separate study examined growth-hormone pulsatility under sustained exposure. These are surrogate endocrine endpoints, not controlled evidence of a patient-centered benefit. FDA flags possible immunogenicity and peptide-related impurity characterization problems for compounded CJC-1295, limited clinical data, and reports of serious events such as increased heart rate and systemic vasodilatory reaction.

Important limitation

Small, short studies in healthy adults do not establish long-term safety or a disease-treatment effect. The investigated substance and formulation are not automatically equivalent to a seller’s vial. This page does not recommend hormone modulation, preparation, administration, or any amount.

Research references

Calculation boundary

The calculator performs concentration arithmetic only when a user enters a mass and liquid volume. It does not verify identity, formulation, purity, sterility, stability, compatibility, biological-unit equivalence, or whether reconstitution applies to a particular product. Do not convert IU or other biological units to mg without an authoritative, exact-product relationship.

For research purposes only. This page is educational and is not medical or veterinary advice or a recommendation to purchase, prepare, administer, or use any product.

Continue exploring

These pages share a research topic (Growth-hormone releasing-hormone research). A link does not mean the compounds have the same mechanism, evidence, formulation, or use.

GHRH(1–29) analogue Sermorelin View research profile Non-DAC GHRH analogue designation CJC-1295 (no DAC) View research profile
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