FOXO4-DRI

FOXO4-DRI is an experimental peptide designed to disrupt a FOXO4–p53 interaction in senescent-cell models. Cell and mouse findings are not proof of a safe or effective anti-aging treatment.

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Generic research visual — not a commercial product

Compound typeEngineered D-retro-inverso peptide

Evidence baseCell and mouse experiments

Regulatory contextInvestigational / Not FDA-approved

Page purposeResearch and calculation

Compound calculator

FOXO4-DRI reconstitution calculator

Enter the values printed on your vial and the liquid volume you added to calculate concentration, liquid volume, and the corresponding mark on a U-100 syringe scale.

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Enter the three required values to see the mathematical result.

This calculator performs arithmetic using values you enter. It does not select or recommend an amount, schedule, treatment, preparation method, or method of administration.

Research overview

What is FOXO4-DRI?

FOXO4 is a transcription factor implicated in survival of some senescent cells. FOXO4-DRI is an engineered peptide investigated for interfering with its interaction with p53. The “DRI” design refers to a D-retro-inverso strategy; the label does not independently verify that a supplied peptide has the studied structure.

What has research examined?

A foundational paper reported selective apoptosis of senescent cells under tested culture conditions and improvements in selected tissue and functional measurements in accelerated-aging and naturally aged mice. Another experiment examined senescent Leydig cells and testosterone-related measures in aged mice. These preclinical settings do not establish prevention of human aging, broader selectivity, or long-term safety.

Important limitation

Removing senescent cells in selected experimental models is not a validated human healthspan outcome. Off-target effects and translation to people remain unresolved. No preparation, amount, schedule, or use is recommended.

Research references

Calculation boundary

The calculator performs concentration arithmetic only when a user enters a mass and liquid volume. It does not verify identity, formulation, purity, sterility, stability, compatibility, biological-unit equivalence, or whether reconstitution applies to a particular product. Do not convert IU or other biological units to mg without an authoritative, exact-product relationship.

For research purposes only. This page is educational and is not medical or veterinary advice or a recommendation to purchase, prepare, administer, or use any product.