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eHealthTutorial — Research Peptide Reviews
Investigational triple agonist • Not FDA-approved

GIP/GLP-1/glucagon receptor research

Retatrutide

Retatrutide is a triple-receptor agonist studied in controlled metabolic trials. It is investigational, not an FDA-approved weight-management drug.

Explore the research
Generic research visual — not a commercial product
Compound typeGIP/GLP-1/glucagon receptor agonist peptide
Evidence baseControlled phase 2 and ongoing phase 3 studies
Regulatory contextInvestigational / Not FDA-approved
Page purposeResearch overview
Why there is no compound calculator on this page

FDA identifies retatrutide as an unapproved GLP-1 drug and has challenged marketing/compounding of retatrutide products. A syringe measurement diagram would not establish regulated product quality or authorized use.

Research overview

What is Retatrutide?

Retatrutide (LY3437943) is designed to stimulate three hormone receptors: GIP, GLP-1, and glucagon. It should not be conflated with tirzepatide, which targets GIP and GLP-1, or with mazdutide, which targets GLP-1 and glucagon. An investigational clinical product is not equivalent to a supplier vial.

What has research examined?

A 338-participant placebo-controlled phase 2 trial reported dose-group-dependent weight change at studied endpoints, with adverse effects predominantly gastrointestinal. Later phase 3 programs are product-specific and do not establish FDA approval. FDA has issued concerns and enforcement action regarding unapproved retatrutide products marketed outside the clinical development setting.

Important limitation

A trial effect cannot be assigned to an unverified research powder or converted into dosing advice. This page gives no treatment, amount, syringe, or preparation instruction.

Research references

Calculation boundary

FDA identifies retatrutide as an unapproved GLP-1 drug and has challenged marketing/compounding of retatrutide products. A syringe measurement diagram would not establish regulated product quality or authorized use.

For research purposes only. This page is educational and is not medical or veterinary advice or a recommendation to purchase, prepare, administer, or use any product.