IGF-1 LR3

IGF-1 LR3 is a modified insulin-like growth factor-I analogue with reduced binding to IGF-binding proteins in experimental systems. Animal and cell-culture findings are not a human muscle-growth claim.

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Generic research visual — not a commercial product

Compound typeModified IGF-1 protein analogue

Evidence baseAnimal and laboratory studies; limited direct human outcomes

Regulatory contextInvestigational / Not FDA-approved

Page purposeResearch and calculation

Compound calculator

IGF-1 LR3 reconstitution calculator

Enter the values printed on your vial and the liquid volume you added to calculate concentration, liquid volume, and the corresponding mark on a U-100 syringe scale.

Your IGF-1 LR3 calculation appears here

Enter the three required values to see the mathematical result.

This calculator performs arithmetic using values you enter. It does not select or recommend an amount, schedule, treatment, preparation method, or method of administration.

Research overview

What is IGF-1 LR3?

Long R3 IGF-I differs from native IGF-I by an N-terminal extension and an arginine substitution near residue three. These modifications reduce affinity for some IGF-binding proteins. Recombinant Long R3 material is used as a cell-culture reagent, and those laboratory uses do not establish a medicine for independently sourced vials.

What has research examined?

A guinea-pig infusion study compared long R3 IGF-I with other growth factors and measured organ growth and circulating IGF-system components; its authors noted reduced IGF-binding-protein affinity. A newer fetal-sheep experiment did not find the predicted growth benefit in a growth-restricted setting. These results illustrate context-dependent animal effects rather than a reliable human physique or recovery outcome.

Important limitation

Animal growth measures and cell-culture reagents do not establish safety, treatment, or performance effects in humans. The analogue should not be conflated with any approved mecasermin formulation. No amount, schedule, preparation, or use is recommended.

Research references

Long R3 IGF-I infusion stimulates organ growth but reduces IGF-system concentrations in guinea pigsJournal of Endocrinology; animal study
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheepPediatric Research; animal study

Calculation boundary

The calculator performs concentration arithmetic only when a user enters a mass and liquid volume. It does not verify identity, formulation, purity, sterility, stability, compatibility, biological-unit equivalence, or whether reconstitution applies to a particular product. Do not convert IU or other biological units to mg without an authoritative, exact-product relationship.

For research purposes only. This page is educational and is not medical or veterinary advice or a recommendation to purchase, prepare, administer, or use any product.